Clinical pharmacology. Drug development.

Clinical drug development--practical issues in clinical pharmacology studies.

INTRODUCTION Clinical pharmacology refers to the study of the safety, pharmacodynamic activity, mechanism of action, pharmacokinetics, metabolism and excretion of a drug in man. METHODS Selected review of topics that provide guidance on practical issues for researchers conducting non-therapeutic investigational research in humans. RESULTS Close attention to the issues highlighted is needed ...

The importance of clinical pharmacology in drug development.

Pralatrexate pharmacology and clinical development.

Folates are well known to be essential for many cellular processes, including cellular proliferation. As a consequence, antifolates, the fraudulent mimics of folic acid, have been shown to be potent therapeutic agents in many cancers. Over the past several decades, efforts to improve on this class of drugs have met with little success. Recently, one analog specifically designed to have high aff...

Clinical pharmacology = disease progression + drug action.

Clinical pharmacology is concerned with understanding how to use medicines to treat disease. Pharmacokinetics and pharmacodynamics have provided powerful methodologies for describing the time course of concentration and effect in individuals and in populations. This population approach may also be applied to describing the progression of disease and the action of drugs to change disease progres...

Managing Drug Toxicities & Drug Interactions: Clinical Pharmacology Case-based Discussion

Introduction A drug interaction occurs when one drug alters the pharmacological effect (enhanced or decreased) of another drug. In human medicine there are several resources available to screen for drug interactions, and there are specific guidelines and agencies to report suspected drug interactions to. In veterinary medicine screening, monitoring, and reporting of drug interactions are rarely...